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KMID : 1007520160250010247
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Food Science and Biotechnology
2016 Volume.25 No. 1 p.247 ~ p.252
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Molecular Structure and Anti-proliferative Effect of Galangin in HCT-116 Cells: In vitro Study
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Ghassan Mohammad Sulaiman
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Abstract
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Galangin is a naturally occurring plant flavonoid with potential anticancer activity. In present work, the Becke three-parameter hybrid exchange functional method and the Lee-Yang-Parr correction functional methods were used to investigate the structural properties of galangin. The structure-activity relationship analysis has been performed to determine its antioxidant pharmacophore by using density functional theory method and quantum chemical calculations. The free radical scavenging activities of galangin were analyzed with the use of 2, 2-diphenyl-1-picrylhydrazyl and compared with Vitamin C as a control. Galangin decreased the cell proliferation rate in HCT-116 cells and showed concentration- and time-dependent response. Galangin significantly increase the inhibitory effect on HCT-116 clonogenicity and promotes cell cycle arrest at the G2/M or G1 phase, as confirmed by flow cytometry analysis.
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KEYWORD
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galangin, molecular structure, clonogenicity, cell cycle, HCT-116
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